Trends in motor neuron disease mortality in the United States from 1999 to 2020.

BACKGROUND

Motor neuron disease (MND) is a rare, fatal neurodegenerative disorder associated with high mortality and disability, posing a significant healthcare burden. This study analyzed the United States mortality trends from 1999 to 2020 using data from the CDC WONDER database.

METHODS

A retrospective analysis was conducted, calculating age-adjusted mortality rates (AAMRs per 100,000) and annual percentage changes, with stratification by age, sex, race, and census region.

RESULTS

There were 140,805 MND-related deaths during the period. The overall mortality rate remained stable from 1999-2015 and 2016-2020. Rates varied significantly by age, being highest in the 75-84 group and lowest in the 25-34 group. Mortality was highest among males and non-Hispanic whites. The AAMR was also highest in the Midwest and in rural areas.

CONCLUSION

In conclusion, while overall MND mortality in the U.S. was stable, the age-adjusted rate was highest among men, non-Hispanic whites, and rural populations in the Midwest, and increased with age. This underscores the need for targeted interventions, including education, environmental improvements, enhanced healthcare access, and screening promotion for high-risk groups.