Mental health, quality of life and associated factors in adults with celiac disease.

Aim: this study aimed to assess health-related quality of life (HRQoL) and depressive symptoms in adult celiac disease (CD) patients and to evaluate the impact of sociodemographic and clinical factors on these outcomes. Methods: in this cross-sectional study, 52 adult CD patients and 40 age- and sex-matched healthy controls were enrolled. HRQoL was assessed using the CD-QOL questionnaire and depressive symptoms were evaluated with the Beck Depression Inventory-II (BDI-II). Sociodemographic and clinical data were collected. This is first study to conducted on this topic Turkish adult CD patients. Results: the mean CD-OQL total score was 126.8 ± 24.1, Emotion (28.1 ± 9.5) and Worries (29.6 ± 7.3) being the most impaired subscales. Age at diagnosis was significantly negatively correlated with CD-QOL total, Emotion and GI symptoms (p < 0.05), while disease duration showed positive correlation with CD-QOL total and all subscales, except Social domain (p > 0.05). There were significant differences in CD-QoL total and subscales across education levels and income groups (p = 0.03 vs p = 0.02). Approximately 26.9 % of CD patients had clinical depression, significantly higher than controls (p  =  0.002). BDI scores showed a strong negative correlation with CD-QOL total and all subscales (p < 0.01). BDI score was better in high income patients, while no difference was found among education levels. GFD adherence did not significantly affect CD-QOL or depression scores (p > 0.05). Conclusion: CD patients face substantial psychological and socioeconomic challenges. These findings highlight the need for routine HRQoL and mental health screening in CD management to improve long-term outcomes beyond dietary control.