Immunity · 2012
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Hall Aisling O'Hara, Beiting Daniel P, Tato Cristina, John Beena, Oldenhove Guillaume, Lombana Claudia Gonzalez, Pritchard Gretchen Harms, Silver Jonathan S, Bouladoux Nicolas, Stumhofer Jason S, Harris Tajie H, Grainger John, Wojno Elia D Tait, Wagage Sagie, Roos David S, Scott Philip, Turka Laurence A, Cherry Sara, Reiner Steven L, Cua Daniel, Belkaid Yasmine, Elloso M Merle, Hunter Christopher A
Аннотация
Interferon-γ (IFN-γ) promotes a population of T-bet(+) CXCR3(+) regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with Toxoplasma gondii, a similar population emerged that limited T cell responses and was dependent on IFN-γ in the periphery but on IL-27 at mucosal sites. Transfer of Treg cells ameliorated the infection-induced pathology observed in Il27(-/-) mice, and this was dependent on their ability to produce IL-10. Microarray analysis revealed that Treg cells exposed to either IFN-γ or IL-27 have distinct transcriptional profiles. Thus, IFN-γ and IL-27 have different roles in Treg cell biology and IL-27 is a key cytokine that promotes the development of Treg cells specialized to control Th1 cell-mediated immunity at local sites of inflammation.
Предметные рубрики MeSH
AnimalsCell DifferentiationCells, CulturedFemaleFlow CytometryForkhead Transcription FactorsGene Expression ProfilingInterferon-gammaInterleukin-17MaleMiceMice, Inbred C57BLMice, Inbred CBAMice, KnockoutMice, TransgenicOligonucleotide Array Sequence AnalysisReceptors, CXCR3STAT1 Transcription FactorSalmonella Infections, AnimalSalmonella typhimuriumT-Box Domain ProteinsT-Lymphocytes, RegulatoryToxoplasmaToxoplasmosis, AnimalT-bet Transcription Factor