The future of targeted therapies for pediatric central nervous system tumors.

Targeted therapies are changing the landscape of pediatric brain tumor management. They offer the opportunity of more effective and personalized treatment strategies, with reduced side effects and improved outcomes. This paradigm shift in pediatric neuro-oncology is still at an early stage, and this review summarizes ongoing research that aims at finding novel drugs or at improving the management of pediatric low- and high-grade gliomas, ependymomas, embryonal tumors, germ cell tumors, craniopharyngiomas, and choroid plexus carcinomas.