Journal of ethnopharmacology · 2026
Angelica dahurica alleviates migraine via ameliorating neuroinflammation and oxidative stress.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yu Dan, Song Huipeng, Wang Tianmin, Li Na, Cai Mingchen, Zhang Dachuan, Li Siyu, Zhang Hui
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: Angelica dahurica radix (ADR), originating from Shennong Bencao Jing, is renowned for its ability to resolve the exterior, disperse cold, and relieve pain. ADR has a history of over one thousand years in treating headache and migraine.
AIM OF THE STUDY: Neuroinflammation and oxidative stress are critical drivers of migraine pathology. Angelica dahurica (ADR), a venerable medicinal and edible herb derived from Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. or its variety formosana, demonstrates significant anti-migraine potential; however, its bioactive profile and underlying immunopharmacological mechanisms remain elusive.
MATERIALS AND METHODS: In this study, we established a comprehensive strategy integrating chemical profiling with systems biology to decode the efficacy of ADR. Using UHPLC-Q-TOF-MS/MS, HS-SPME-GC-MS, and molecular networking, we characterized the chemical constituents and identified bioavailable compounds in the bloodstream. In a nitroglycerin (NTG)-induced rat migraine model, ADR treatment remarkably reversed hyperalgesia. Crucially, an integrated non-targeted metabolomics and transcriptomics analysis, validated by Western blot and immunohistochemistry, unveiled the core therapeutic network.
RESULTS: We identified byakangelicin, oxypeucedanin hydrate, and bergapten as key absorbed bioactive components. Mechanistically, these compounds exert potent neuroprotective effects by blockading the TRPV1/CaMKII axis and the GNA11/ERK/COX-2 inflammatory cascade.
CONCLUSION: This study provides novel insights into the pharmacological basis of ADR.
AIM OF THE STUDY: Neuroinflammation and oxidative stress are critical drivers of migraine pathology. Angelica dahurica (ADR), a venerable medicinal and edible herb derived from Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. or its variety formosana, demonstrates significant anti-migraine potential; however, its bioactive profile and underlying immunopharmacological mechanisms remain elusive.
MATERIALS AND METHODS: In this study, we established a comprehensive strategy integrating chemical profiling with systems biology to decode the efficacy of ADR. Using UHPLC-Q-TOF-MS/MS, HS-SPME-GC-MS, and molecular networking, we characterized the chemical constituents and identified bioavailable compounds in the bloodstream. In a nitroglycerin (NTG)-induced rat migraine model, ADR treatment remarkably reversed hyperalgesia. Crucially, an integrated non-targeted metabolomics and transcriptomics analysis, validated by Western blot and immunohistochemistry, unveiled the core therapeutic network.
RESULTS: We identified byakangelicin, oxypeucedanin hydrate, and bergapten as key absorbed bioactive components. Mechanistically, these compounds exert potent neuroprotective effects by blockading the TRPV1/CaMKII axis and the GNA11/ERK/COX-2 inflammatory cascade.
CONCLUSION: This study provides novel insights into the pharmacological basis of ADR.