Brown Recluse Spider Bite Superimposed With Methicillin-Resistant Staphylococcus aureus Infection: A Case Report.

Brown recluse spider (BRS) bites are known for their potential to cause localized dermonecrosis and, in severe cases, systemic complications such as loxoscelism. However, secondary infections following envenomation are rare and can dramatically alter the clinical course. We present the case of a 52-year-old male who developed progressive cellulitis, tissue necrosis, and abscess formation after a confirmed BRS bite to the left leg. Imaging revealed extensive subcutaneous fluid collections, and surgical drainage confirmed superimposed methicillin-resistant Staphylococcus aureus (MRSA) infection. The atypical features of this case, including timing of presentation outside the typical seasonal pattern and the development of a secondary bacterial infection, highlight the need for clinicians to recognize and manage unusual complications of BRS bites. Prompt diagnosis, aggressive antibiotic therapy, multidisciplinary consultation, and surgical intervention were critical in preventing further morbidity. This case emphasizes the importance of considering secondary infections in patients with worsening symptoms following envenomation.