Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2010
Resting state eyes-closed cortical rhythms in patients with locked-in-syndrome: an EEG study.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Babiloni Claudio, Pistoia Francesca, Sarà Marco, Vecchio Fabrizio, Buffo Paola, Conson Massimiliano, Onorati Paolo, Albertini Giorgio, Rossini Paolo Maria
Аннотация
OBJECTIVE: Locked-in syndrome (LIS) is a state of complete paralysis, except for ocular movements, which results from ventral brainstem lesions. Patients typically are fully conscious. Here we tested the hypothesis that electroencephalographic (EEG) rhythms are abnormal in LIS patients, possibly due to an impaired neural synchronization between brainstem and cerebral cortex.
METHODS: Resting state eyes-closed EEG data were recorded in 13 LIS subjects and 15 cognitively normal control subjects. With reference to the individual alpha frequency (IAF), the bands of interest were delta (IAF-8 to IAF-6Hz), theta (IAF-6 to IAF-4Hz), alpha 1 (IAF-4 to IAF-2Hz), alpha 2 (IAF-2 to IAFHz), and alpha 3 (IAF to IAF+2Hz). Furthermore, beta 1 (13-20Hz) and beta 2 (20-30Hz) bands were also considered. Cortical EEG sources were estimated by low-resolution electromagnetic tomography (LORETA).
RESULTS: The power of alpha 2 and alpha 3 sources in all regions was lower in patients with LIS compared to controls. The power of delta sources in central, parietal, occipital and temporal regions was higher in patients with LIS compared to controls.
CONCLUSIONS: These results suggest that cortical sources of resting state eyes-closed alpha and delta rhythms are abnormal in LIS patients.
SIGNIFICANCE: LIS is accompanied by a functional impairment of cortical neuronal synchronization mechanisms in the resting state condition.
METHODS: Resting state eyes-closed EEG data were recorded in 13 LIS subjects and 15 cognitively normal control subjects. With reference to the individual alpha frequency (IAF), the bands of interest were delta (IAF-8 to IAF-6Hz), theta (IAF-6 to IAF-4Hz), alpha 1 (IAF-4 to IAF-2Hz), alpha 2 (IAF-2 to IAFHz), and alpha 3 (IAF to IAF+2Hz). Furthermore, beta 1 (13-20Hz) and beta 2 (20-30Hz) bands were also considered. Cortical EEG sources were estimated by low-resolution electromagnetic tomography (LORETA).
RESULTS: The power of alpha 2 and alpha 3 sources in all regions was lower in patients with LIS compared to controls. The power of delta sources in central, parietal, occipital and temporal regions was higher in patients with LIS compared to controls.
CONCLUSIONS: These results suggest that cortical sources of resting state eyes-closed alpha and delta rhythms are abnormal in LIS patients.
SIGNIFICANCE: LIS is accompanied by a functional impairment of cortical neuronal synchronization mechanisms in the resting state condition.