Platelet indices as prognostic markers of vascular complications in type-2 diabetes mellitus.

With its rising incidence and substantial risk of microvascular and macrovascular consequences, diabetes mellitus (DM) is a serious health concern of global magnitude. Therefore, it is of interest to determine the distribution of platelet indices in type 2 diabetes mellitus (T2DM) patients with and without vascular complications and assess their potential as predictive biomarkers. The cross-sectional study was undertaken over 18 months, which included 107 diagnosed T2DM patients and 69 age and gender-matched healthy controls. Platelet count and MPV were significantly altered in diabetics, especially among those with complications, whereas PDW showed no significant difference and logistic regression displayed a significant correlation of abnormal platelet count (Adjusted OR: 2.95, 95% CI: 1.23-7.06; p=0.015) and MPV (Adjusted OR: 0.31, 95% CI: 0.10-0.92; p=0.036) with vascular complications. Platelet count and MPV are promising, economical biomarkers for the early prediction of vascular complications in T2DM patients and their frequent monitoring may lead to early disease detection, timely anagement and better clinical outcomes.