Non-invasive biomarkers of gastric function from body surface gastric mapping and their role in chronic gastroduodenal disorders.

INTRODUCTION

Chronic gastroduodenal disorders are highly prevalent with significant impact on patients and healthcare systems, yet their diagnosis and specific management remain challenging. Patients with gastroparesis and overlapping disorders of the gut-brain interaction frequently lack actionable biomarkers of specific underlying pathophysiologies with which to direct care.

AREAS COVERED: The recent emergence of novel noninvasive biomarkers related to underlying contributory disease mechanisms, enabled by body-surface gastric mapping systems, offers a significant opportunity to advance diagnosis and personalized care. These biomarkers, their associated platforms, and their arising clinical implications are reviewed.

EXPERT OPINION: A spectrum of motor and sensory mechanisms is known to contribute to chronic gastroduodenal symptoms, yet these mechanisms are not adequately addressed by current diagnostic tools, disease nomenclature, or management guidelines. A mechanism-centric diagnostic platform, enabled by new noninvasive actionable biomarkers, presents a significant opportunity to advance care in neurogastroenterology.