Treatment of ulcerative necrobiosis lipoidica with topical calcineurin inhibitor: case report and literature review.

BACKGROUND

Ulcerative necrobiosis lipoidica (UNL) is an uncommon disease, which is frequently recalcitrant to available therapies. It is characterized by well-defined, ulcerated plaques with indurated borders and atrophic centers. Multiple therapeutic options have been described, with variable success rates.

OBJECTIVE

To report the efficacy of using topical tacrolimus in treating UNL.

METHOD: Topical tacrolimus was used in the treatment of two patients with UNL.

RESULT: Topical tacrolimus is effective in treating UNL.

CONCLUSION

Topical tacrolimus is a reasonably effective choice in treating UNL.