Crohn's & colitis 360 · 2021
The Clinical Characteristics and Treatment Outcomes of Concomitant Eosinophilic Esophagitis and Inflammatory Bowel Disease.
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Urquhart Siri A, Quinn Kevin P, Ravi Karthik, Loftus Edward V
Аннотация
BACKGROUND: The clinical characteristics and treatment outcomes in patients with eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) have not been extensively investigated.
METHODS: We determined treatment outcomes and frequencies of disease-related complications in patients with EoE and IBD.
RESULTS: Among 69 patients who met inclusion criteria, 39 (56.5%) had a diagnosis of Crohn disease. Clinical and histologic response rates to proton pump inhibitors and topical steroids were 25.9% and 24.4%, respectively.
CONCLUSIONS: Lower than expected clinical and histologic response rates for EoE suggest the combination of EoE and IBD is a medically refractory phenotype with more difficult to treat EoE.
METHODS: We determined treatment outcomes and frequencies of disease-related complications in patients with EoE and IBD.
RESULTS: Among 69 patients who met inclusion criteria, 39 (56.5%) had a diagnosis of Crohn disease. Clinical and histologic response rates to proton pump inhibitors and topical steroids were 25.9% and 24.4%, respectively.
CONCLUSIONS: Lower than expected clinical and histologic response rates for EoE suggest the combination of EoE and IBD is a medically refractory phenotype with more difficult to treat EoE.