International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
Cerebral vasculitis due to Aspergillus spp. in immunocompromised patients: literature review.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Haddad Elie, Fekkar Arnaud, Bonnin Sophie, Shor Natalia, Seilhean Danielle, Plu Isabelle, Touitou Valérie, Leblond Véronique, Weiss Nicolas, Demeret Sophie, Pourcher Valérie
Аннотация
OBJECTIVES: Invasive aspergillosis is a threat for immunocompromised patients. We present a case series of aggressive cerebral vasculitis caused by Aspergillus spp. infection in immunocompromised patients.
METHODS: We present a retrospective case series of three autopsy-proven invasive cerebral aspergillosis with diffuse vasculitis affecting large caliber cerebral vessels.
RESULTS: Three patients were immunosuppressed: one on rituximab, one on corticosteroids, and one with a renal transplant. Two of these patients were diagnosed with cerebral aspergillosis on postmortem.
CONCLUSION: Aspergillus cerebral vasculitis is a rare form of invasive aspergillosis that should be considered in an immunocompromised individual with suggestive lesions on imaging. It should be suspected as a possible cause of aseptic neutrophil meningitis.
METHODS: We present a retrospective case series of three autopsy-proven invasive cerebral aspergillosis with diffuse vasculitis affecting large caliber cerebral vessels.
RESULTS: Three patients were immunosuppressed: one on rituximab, one on corticosteroids, and one with a renal transplant. Two of these patients were diagnosed with cerebral aspergillosis on postmortem.
CONCLUSION: Aspergillus cerebral vasculitis is a rare form of invasive aspergillosis that should be considered in an immunocompromised individual with suggestive lesions on imaging. It should be suspected as a possible cause of aseptic neutrophil meningitis.