Frontiers in surgery · 2026
Development of an experimental model for vascularized adrenal gland transplantation in rats.
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Ozcan Cumhur, Hazinedaroglu Selcuk Mevlut, Tug Tugbay
Аннотация
AIM: The adrenal gland is a vital endocrine organ responsible for maintaining physiological homeostasis. Bilateral adrenalectomy results in adrenal insufficiency, requiring lifelong hormone replacement therapy. This study aimed to establish a reproducible experimental model for vascularized adrenal gland transplantation in rats.
MATERIALS AND METHODS: Twenty male Wistar Albino rats (180-220 g) were randomly assigned into two equal groups (n = 10 each): control and transplantation. The control group underwent bilateral total adrenalectomy. In the transplantation group, vascularized adrenal grafts-including the adrenal artery and vein with attached aortic and inferior vena cava segments-were anastomosed end-to-side to the recipient's femoral artery and vein using 10-0 nylon sutures under general anesthesia. On postoperative day 15, all recipients underwent bilateral adrenalectomy. On day 100, animals were sacrificed for macroscopic and histopathological evaluation of graft viability.
RESULTS: All control rats died within 15 days, whereas all transplanted rats survived throughout the 100-day observation period. Macroscopic inspection revealed viable grafts without vascular compromise. Histopathological analysis demonstrated preserved cortical and medullary architecture, confirming the long-term viability of the transplanted adrenal glands.
CONCLUSION: This study presents a technically feasible and reproducible model for vascularized adrenal gland transplantation in rats. The model provides a reliable experimental platform for future research on adrenal physiology and transplantation surgery.
MATERIALS AND METHODS: Twenty male Wistar Albino rats (180-220 g) were randomly assigned into two equal groups (n = 10 each): control and transplantation. The control group underwent bilateral total adrenalectomy. In the transplantation group, vascularized adrenal grafts-including the adrenal artery and vein with attached aortic and inferior vena cava segments-were anastomosed end-to-side to the recipient's femoral artery and vein using 10-0 nylon sutures under general anesthesia. On postoperative day 15, all recipients underwent bilateral adrenalectomy. On day 100, animals were sacrificed for macroscopic and histopathological evaluation of graft viability.
RESULTS: All control rats died within 15 days, whereas all transplanted rats survived throughout the 100-day observation period. Macroscopic inspection revealed viable grafts without vascular compromise. Histopathological analysis demonstrated preserved cortical and medullary architecture, confirming the long-term viability of the transplanted adrenal glands.
CONCLUSION: This study presents a technically feasible and reproducible model for vascularized adrenal gland transplantation in rats. The model provides a reliable experimental platform for future research on adrenal physiology and transplantation surgery.