Investigation of the Relationship Between Minor Salivary Gland Biopsy Findings and Pan-Immune-Inflammation Value (PIV) and Systemic Inflammation Response Index (SIRI).

BACKGROUND

Systemic inflammation indices derived from complete blood count parameters have recently gained attention as potential biomarkers in autoimmune diseases.

AIM: This study aimed to investigate the relationship between minor salivary gland biopsy results with the pan-immune-inflammation value (PIV) and systemic inflammation response index (SIRI).

METHODS

File records of patients who underwent minor salivary gland biopsy at the Otorhinolaryngology Department between December 01, 2020 and May 01, 2023 were reviewed. In Group 1, the lymphocytic infiltration focus score was ≤1, whereas in Group 2, it was >1. Group 1 and Group 2 were statistically compared in terms of age, sex, complete blood test parameters, PIV, and SIRI.

RESULTS

Data from 200 patients were included in the study. There were 71 patients (35.5%) in Group 1 and 129 patients (64.5%) in Group 2. No significant differences were found between the groups in terms of white blood cell count, neutrophil count, lymphocyte count, monocyte count, platelet count, and PIV values (P-values: 0.248, 0.148, 0.232, 0.061, 0.071, and 0.056, respectively). A significant difference was observed only for the SIRI value, which was lower in Group 2 (P = 0.012).

CONCLUSION

Our findings support the possibility that there may not be a parallel relationship between local glandular inflammation and systemic immune response. Systemic inflammation indices such as SIRI and PIV should be interpreted with caution in the context of disease phenotype, pattern of tissue involvement, and immune cell distribution.