Translational vision science & technology · 2026
Ocular Transmission of Red and Violet Light: Insights into Light-Based Myopia Therapies.
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Priscilla Jacinth J, Beach Krista M, Maldoddi Rakesh, Schill Alexander W, Ostrin Lisa A
Аннотация
PURPOSE: The purpose of this study was to determine transmission of red and violet light through ocular tissues, providing insight into how much light from light-based myopia control instruments reaches each tissue.
METHODS: Fresh porcine eyes (n = 5, axial length = 22.40 ± 1.52 mm) were dissected to isolate the cornea, lens, retina, retinal pigment epithelium (RPE)/choroid, and sclera. Light transmission was measured for a red laser (654 nm), red light-emitting diodes (LEDs; 660 nm), and violet LEDs (396 nm). Transmission was quantified using a radiometer. Mean transmission values were compared using 1-way ANOVA with Bonferroni post hoc tests.
RESULTS: Corneal, lenticular, and retinal transmission were significantly lower for light emitted from violet LEDs compared with red laser and red LEDs (P < 0.05 for all). Light from the red laser showed reduced retinal transmission relative to the light from the red LEDs (P = 0.03). Power of light incident on the posterior sclera, considering cumulative transmission through the anterior ocular structures, was 1.66 µW (0.6%) for the red laser (with Maxwellian), 0.37 µW (0.6%) for the red laser, 2.79 µW (0.9%) for red LEDs, and 5.85 µW (0.1%) for violet LEDs.
CONCLUSIONS: Red light exhibited greater penetration through ocular tissues than violet light. Violet light was more strongly attenuated by the cornea and lens, demonstrating limited retinal delivery. The choroid acted as a major barrier to all light sources.
TRANSLATIONAL RELEVANCE: Understanding transmission efficiency of red and violet light through ocular tissues is a critical first step in finding a mechanistic link to biological pathways underlying light-mediated myopia control strategies.
METHODS: Fresh porcine eyes (n = 5, axial length = 22.40 ± 1.52 mm) were dissected to isolate the cornea, lens, retina, retinal pigment epithelium (RPE)/choroid, and sclera. Light transmission was measured for a red laser (654 nm), red light-emitting diodes (LEDs; 660 nm), and violet LEDs (396 nm). Transmission was quantified using a radiometer. Mean transmission values were compared using 1-way ANOVA with Bonferroni post hoc tests.
RESULTS: Corneal, lenticular, and retinal transmission were significantly lower for light emitted from violet LEDs compared with red laser and red LEDs (P < 0.05 for all). Light from the red laser showed reduced retinal transmission relative to the light from the red LEDs (P = 0.03). Power of light incident on the posterior sclera, considering cumulative transmission through the anterior ocular structures, was 1.66 µW (0.6%) for the red laser (with Maxwellian), 0.37 µW (0.6%) for the red laser, 2.79 µW (0.9%) for red LEDs, and 5.85 µW (0.1%) for violet LEDs.
CONCLUSIONS: Red light exhibited greater penetration through ocular tissues than violet light. Violet light was more strongly attenuated by the cornea and lens, demonstrating limited retinal delivery. The choroid acted as a major barrier to all light sources.
TRANSLATIONAL RELEVANCE: Understanding transmission efficiency of red and violet light through ocular tissues is a critical first step in finding a mechanistic link to biological pathways underlying light-mediated myopia control strategies.