Helicobacter pylori-associated gastritis and gastric carcinoma in Beijing.

A retrospective study was performed on 500 consecutive gastric biopsies obtained from patients with a diagnosis of gastritis and gastric carcinoma. Overall, Helicobacter pylori was detected in 336 cases (67.2%); it was seen in 82.4% of patients with duodenal ulcer, 80.1% of patients with gastric ulcer, 76.1% of patients with chronic atrophic gastritis, 60.3% of patients with chronic superficial gastritis, and 32.1% of patients with gastric carcinoma. The gastric epithelium colonized by Helicobacter pylori showed characteristic changes including loss of the apical mucous portion of individual cells, dropout of epithelial cells, and erosions. There is a strong suggestion that the inflammation associated with Helicobacter pylori infection plays a role in the pathogenesis of gastric carcinoma.