Relationship of Carotid-Femoral Pulse Wave Velocity and Brachial-Ankle Pulse Wave Velocity With the Risk of New-Onset Cardiovascular Events: A Cohort Study in the Beijing Community-Based Population.

Carotid-femoral pulse wave velocity (cfPWV) and brachial-ankle pulse wave velocity (baPWV) are widely used indicators of arterial stiffness, with cfPWV considered the gold standard and baPWV increasingly applied in Asian populations. In this community-based cohort from Beijing, we compared the associations of cfPWV and baPWV with the risk of new-onset cardiovascular events. A total of 5723 residents from the Shougang community with available cfPWV and baPWV measurements from the 2018 follow-up survey were included. CfPWV was measured using Pulsepen and baPWV using the Omron BP-203RPE III device. Cardiovascular events, defined as a composite outcome of cardiovascular death, first-ever myocardial infarction, or stroke, were identified from national and municipal registries through December 31, 2021. Over a median follow-up of 3.15 years, 173 cardiovascular events occurred. Both cfPWV and baPWV were associated with incident cardiovascular events in Kaplan-Meier analyses. However, in multivariable Cox regression models adjusting for traditional cardiovascular risk factors, cfPWV showed a nonsignificant trend (p = 0.072), while baPWV remained significantly associated with new-onset events (p < 0.001). These findings indicate that in this community-based population, baPWV, but not cfPWV, demonstrates a robust association with cardiovascular risk, suggesting that baPWV may serve as a more practical and effective tool for routine cardiovascular risk assessment in Asian populations.