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Войти в исследования Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
GABAA receptor and anti-titin antibody encephalitis in a patient with thymoma.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Tappatà Maria, Giannoccaro Maria Pia, Romoli Michele, Testoni Stefania, Arnone Giorgia, Piccolo Laura, Solli Piergiorgio, Zaniboni Anna, Naldi Federica, Moghadam Keivan Kaveh, Nannini Nazarena, Damiani Stefania, Liguori Rocco, Zini Andrea
Аннотация
Autoimmune encephalitis (AE) associated to antibodies against GABA A R is a rare form of encephalitis. On the other hand, thymoma has been linked to antibodies against both muscular and neuronal epitopes, even if concurrent positivity for more than one antibody is exceptional, and their contribution to the clinical course and treatment decision is unclear. We report a case of a 73-year-old male with AE associated with thymoma secreting both anti-GABAaR and anti-titin antibodies. Clinical presentation included status epilepticus, behavioural changes and cognitive decline. While the status was stopped with lacosamide, AE treatment included first- and second-line immunomodulation, in addition to thymoma's removal. Nonetheless, the patient experienced a worsening in cognitive and behavioural status.