Rectal Methamphetamine Use, a Likely Cause of Sigmoid Colon Perforation: A Case Report.

Methamphetamine has potent stimulant effects on the central nervous system, resulting in significant behavioral and autonomic changes. There is substantial literature on the behavioral and cardiovascular complications of methamphetamine use, but literature on the gastrointestinal complications of methamphetamine use is very sparse. Search of the published literature in English-language journals has not revealed any case of colonic perforation attributable to methamphetamine use. Here, we report a case of perforation of the sigmoid colon in the setting of chronic rectal administration of methamphetamine. A written informed consent to publish this case report was obtained from the patient.