Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026
Zinc-doped carbon dots from natural Isatis Indigotica folium and calamine: SOD/CAT-mimetic activity targets ROS-Ca²⁺-NLRP3 axis for psoriatic dermatitis therapy.
СтатьяНазвание и аннотация: Перевод в очереди
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Tian Xinrong, Huang Yan, He Chenxin, Dai Ertong, Zhang Xiwen, Zou Peng, Liu Ruiyan, Xia Minlong, Lu Zixuan, Jin Bilin, Wang Siqi, Zhang Yue, Kong Hui, Qu Huihua, Zhao Yan
Аннотация
BACKGROUND: Psoriasis is a chronic inflammatory cutaneous disorder characterized by immune dysregulation and aberrant keratinocyte proliferation, necessitating novel effective anti-inflammatory therapies.
PURPOSE: This study synthesized zinc-doped carbon dots (IF+Zn-CDs) from Isatis indigotica Folium and calamine, investigating their therapeutic potential and underlying molecular mechanisms in psoriasis treatment.
STUDY DESIGN: A bottom-up approach prepared IF+Zn-CDs for systematic physicochemical characterization. Their efficacy was assessed in an IMQ-induced murine psoriasis model, with anti-inflammatory mechanisms explored via transcriptomic and mechanistic assays.
METHODS: IF+Zn-CDs were synthesized via bottom-up using the two precursors, characterized by TEM, FTIR, and XPS. An IMQ-induced model evaluated in vivo efficacy; transcriptomic analysis identified modulated pathways, and ROS/intracellular calcium levels clarified NLRP3 regulation, with pyroptosis and MAPK/NF-κB effects validated.
RESULTS: The as-synthesized IF+Zn-CDs exhibited a uniform size distribution, excellent dispersibility, high crystallinity, and superior biocompatibility. In the IMQ-induced murine model of psoriasis, IF+Zn-CDs markedly attenuated psoriatic manifestations including erythema, scaling, epidermal hyperplasia, and inflammatory cell infiltration. Transcriptomic analysis revealed that IF+Zn-CDs modulate multiple signaling pathways associated with psoriatic inflammation. Mechanistic investigations confirmed that IF+Zn-CDs inhibit NLRP3 inflammasome activation through the reduction of ROS production and intracellular calcium levels, and further suppress pyroptosis while blocking the MAPK/NF-κB signaling pathway, ultimately ameliorating psoriasiform dermatitis.
CONCLUSION: IF+Zn-CDs have potent anti-inflammatory activities and ameliorate psoriasiform dermatitis, highlighting their promising potential as novel anti-inflammatory agents for psoriasis.
PURPOSE: This study synthesized zinc-doped carbon dots (IF+Zn-CDs) from Isatis indigotica Folium and calamine, investigating their therapeutic potential and underlying molecular mechanisms in psoriasis treatment.
STUDY DESIGN: A bottom-up approach prepared IF+Zn-CDs for systematic physicochemical characterization. Their efficacy was assessed in an IMQ-induced murine psoriasis model, with anti-inflammatory mechanisms explored via transcriptomic and mechanistic assays.
METHODS: IF+Zn-CDs were synthesized via bottom-up using the two precursors, characterized by TEM, FTIR, and XPS. An IMQ-induced model evaluated in vivo efficacy; transcriptomic analysis identified modulated pathways, and ROS/intracellular calcium levels clarified NLRP3 regulation, with pyroptosis and MAPK/NF-κB effects validated.
RESULTS: The as-synthesized IF+Zn-CDs exhibited a uniform size distribution, excellent dispersibility, high crystallinity, and superior biocompatibility. In the IMQ-induced murine model of psoriasis, IF+Zn-CDs markedly attenuated psoriatic manifestations including erythema, scaling, epidermal hyperplasia, and inflammatory cell infiltration. Transcriptomic analysis revealed that IF+Zn-CDs modulate multiple signaling pathways associated with psoriatic inflammation. Mechanistic investigations confirmed that IF+Zn-CDs inhibit NLRP3 inflammasome activation through the reduction of ROS production and intracellular calcium levels, and further suppress pyroptosis while blocking the MAPK/NF-κB signaling pathway, ultimately ameliorating psoriasiform dermatitis.
CONCLUSION: IF+Zn-CDs have potent anti-inflammatory activities and ameliorate psoriasiform dermatitis, highlighting their promising potential as novel anti-inflammatory agents for psoriasis.