Annals of surgical oncology · 2026
Risk of Ovarian Metastasis in Colorectal Cancer-Related Carcinomatosis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Morgan Ryan B, Neilson Taylor, Keeling Stephanie, Kearse LaDonna, Brown Kilian, Delisle Megan, Ochiai Kentaro, Helmink Beth, Song Yun, Willis Jason, Shen John Paul, Hu Ian, Higbie Victoria S, Feldman Jarett, Morris Van, Matura Kasey, Sadasivan Santosh, You Y Nancy, Bednarski Brian, Konishi Tsuyoshi, Behman Ramy, Moon Jenny, Messick Craig, Guraieb-Trueba Montserrat, Ramamurthy Jagan, Rodriguez-Bigas Miguel, Chang George J, Smith J Joshua, Mansfield Paul, Fournier Keith, White Michael G, Marincola Smith Paula
Аннотация
BACKGROUND: In colorectal cancer (CRC)-related carcinomatosis, the risk of ovarian metastases (OM) is not well described, and practices during cytoreductive surgery (CRS) vary widely. Defining this risk is critical for counseling patients on the necessity of oophorectomy during CRS.
METHODS: This retrospective study analyzed female patients with CRC-related carcinomatosis undergoing curative intent CRS with or without hyperthermic intraperitoneal chemotherapy (HIPEC) at a single center (2008-2024).
RESULTS: The study identified 74 patients, 66% of whom were post-menopausal. The median Peritoneal Cancer Index (PCI) was 8 (interquartile range [IQR], 6-10), and all the patients had a complete cytoreduction (CCR 0/1). Right-sided primary tumors were the most common (57%), and the histology was most commonly non-mucinous (n = 51, 69%), moderately differentiated (n = 49, 66%), and microsatellite stable (n = 67, 90%). Neoadjuvant therapy was common (n = 58, 78%), and 25 (34%) of the patients underwent HIPEC. Four of the patients (5%) had undergone bilateral salpingo-oophorectomy (BSO) before the diagnosis of peritoneal disease. Of the 70 remaining patients, 51 (73%) had grossly abnormal-appearing ovaries. Of the 70 patients, 65 (93%) had a bilateral or completion salpingo-oophorectomy, and 2 (3%) underwent a unilateral oophorectomy. Overall, 55 (79%) of the patients had pathologically confirmed OM. Of the 16 patients with normal-appearing ovaries who underwent oophorectomy, 4 (25%) had microscopic OM. Two (40%) of the five patients with normal-appearing ovaries preserved during CRS experienced ovarian recurrence within 15 months.
CONCLUSIONS: Most of the female patients undergoing CRS for CRC-related carcinomatosis had OM, including 25% of the patients with normal-appearing ovaries. Short-interval recurrence was observed with ovarian preservation. Routine BSO should be strongly considered for patients undergoing CRS with curative intent.
METHODS: This retrospective study analyzed female patients with CRC-related carcinomatosis undergoing curative intent CRS with or without hyperthermic intraperitoneal chemotherapy (HIPEC) at a single center (2008-2024).
RESULTS: The study identified 74 patients, 66% of whom were post-menopausal. The median Peritoneal Cancer Index (PCI) was 8 (interquartile range [IQR], 6-10), and all the patients had a complete cytoreduction (CCR 0/1). Right-sided primary tumors were the most common (57%), and the histology was most commonly non-mucinous (n = 51, 69%), moderately differentiated (n = 49, 66%), and microsatellite stable (n = 67, 90%). Neoadjuvant therapy was common (n = 58, 78%), and 25 (34%) of the patients underwent HIPEC. Four of the patients (5%) had undergone bilateral salpingo-oophorectomy (BSO) before the diagnosis of peritoneal disease. Of the 70 remaining patients, 51 (73%) had grossly abnormal-appearing ovaries. Of the 70 patients, 65 (93%) had a bilateral or completion salpingo-oophorectomy, and 2 (3%) underwent a unilateral oophorectomy. Overall, 55 (79%) of the patients had pathologically confirmed OM. Of the 16 patients with normal-appearing ovaries who underwent oophorectomy, 4 (25%) had microscopic OM. Two (40%) of the five patients with normal-appearing ovaries preserved during CRS experienced ovarian recurrence within 15 months.
CONCLUSIONS: Most of the female patients undergoing CRS for CRC-related carcinomatosis had OM, including 25% of the patients with normal-appearing ovaries. Short-interval recurrence was observed with ovarian preservation. Routine BSO should be strongly considered for patients undergoing CRS with curative intent.