Synchronous Triple Primary Gastrointestinal Tract Malignancies: A Case Report.

Multiple primary malignant neoplasms are defined as the occurrence of two or more distinct malignant neoplasms in a single patient. However, synchronous triple primary malignant neoplasms have rarely been reported. We present the case of a 54-year-old male patient who was referred to our outpatient clinic after abnormal findings were detected during upper gastrointestinal endoscopy screening at a local clinic. Comprehensive evaluation using endoscopy, computed tomography, and positron emission tomography led to the simultaneous diagnosis of early gastric, early esophageal, and sigmoid colon cancers. The patient underwent endoscopic submucosal dissection and simultaneous surgical resection of the other two neoplasms. The patient remained without evidence of recurrence or metastasis at the one-year follow-up.