Specific Micronutrient Intake Association with Diabetic Neuropathy Severity in Adults with Type 2 Diabetes.

BACKGROUND/

OBJECTIVES

Diabetic neuropathy is a prevalent complication of type 2 diabetes mellitus (T2DM), but the contribution of dietary factors to neuropathy severity remains insufficiently characterized. This study investigated associations between dietary patterns, nutrient intake, and neuropathy severity in 300 adults with T2DM from Northeastern Romania.

METHODS

Dietary intake was assessed using a validated food frequency questionnaire, and five dietary patterns were derived using principal component analysis. Neuropathy severity was analyzed as an ordinal outcome using logistic regression models adjusted for age, sex, HbA1c, diabetes duration, and treatment.

RESULTS

Higher adherence to Western/fast-food and alcohol and animal fat dietary patterns was associated with greater neuropathy severity in unadjusted analyses, whereas a healthy/prudent pattern showed inverse associations; however, these relationships were attenuated after multivariable adjustment. In contrast, higher intakes of protein (OR = 0.98, 95% CI: 0.97-0.99), magnesium (OR = 0.99, 95% CI: 0.98-1.00), zinc (OR = 0.80, 95% CI: 0.69-0.94), vitamin B3 (OR = 0.94, 95% CI: 0.89-0.99), and vitamin B12 (OR = 0.76, 95% CI: 0.62-0.93) remained independently associated with lower neuropathy severity after adjustment.

CONCLUSIONS

These findings suggest that specific nutrient intakes may be more strongly associated with diabetic neuropathy severity than overall dietary patterns, highlighting potential nutritional targets for neuropathy risk reduction and clinical management in patients with T2DM.