European journal of gastroenterology & hepatology · 2004
Anti-tissue transglutaminase antibodies in coeliac disease are not a response to gut damage alone.
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Unsworth David J, Pitcher Maxton C L, Stevens Susan, Lock Robert J
Аннотация
BACKGROUND: Anti-tissue transglutaminase (tTG) antibody is being used increasingly as a diagnostic tool in the serological investigation of coeliac disease. However, positive predictive values of immunoglobulin A anti-tTG for coeliac disease in prospective studies have been disappointing.
OBJECTIVE: To determine whether anti-tTG can arise as a non-specific consequence of abnormal gut permeability.
PATIENTS: A cohort from routine investigation for possible gluten-sensitive enteropathy, with 44 cases selected based on whether permeability studies had been performed.
METHODS: The cohort was assessed for anti-tTG by enzyme-linked immunosorbent assay, small-bowel biopsy and C-mannitol absorbency.
RESULTS: Eighteen of the 44 patients had biopsy-proven coeliac disease and 23 showed abnormal permeability. There was poor correlation between the level of anti-tTG and gut permeability.
CONCLUSIONS: These data confirm an association between anti-tTG and coeliac disease but no clear relationship with other forms of increased gut permeability.
OBJECTIVE: To determine whether anti-tTG can arise as a non-specific consequence of abnormal gut permeability.
PATIENTS: A cohort from routine investigation for possible gluten-sensitive enteropathy, with 44 cases selected based on whether permeability studies had been performed.
METHODS: The cohort was assessed for anti-tTG by enzyme-linked immunosorbent assay, small-bowel biopsy and C-mannitol absorbency.
RESULTS: Eighteen of the 44 patients had biopsy-proven coeliac disease and 23 showed abnormal permeability. There was poor correlation between the level of anti-tTG and gut permeability.
CONCLUSIONS: These data confirm an association between anti-tTG and coeliac disease but no clear relationship with other forms of increased gut permeability.