Long-term outcomes and quality of life of laparoscopic-assisted pylorus-preserving gastrectomy compared to laparoscopic-assisted distal gastrectomy with billroth I anastomosis for early gastric cancer(pT1N0M0): A Randomized Controlled Trial.

OBJECTIVE

Clarify the long-term outcomes of laparoscopic-assisted pylorus-preserving gastrectomy (LAPPG) compared to conventional laparoscopic-assisted distal gastrectomy with billroth I anastomosis (LADGBI) for early gastric cancer(pT1N0M0).

METHODS

Patients with cT1N0M0 cancer located in the middle third of the stomach and not suitable for endoscopic submucosal dissection were randomized to undergo LAPPG or LADGBI.

RESULTS

Between August 2017 and October 2019, a total 88 patients (pT1N0M0) were analyzed. The 5-year overall survival rate and disease-free survival rate were 95.5 ​% and 93.2 ​% for LAPPG and 93.2 ​% (P ​= ​0.46) and 91.0 ​% (P ​= ​0.64) for LADGBI. During postoperative 5-year follow up, LAPPG tended to present better functions and less symptoms scales than LADGBI accompanied by effective gallbladder emptying and pylorus function preserving.

CONCLUSION

Surgical and oncological outcomes was comparable in pT1N0M0 patients undergoing LAPPG and LADGBI. LAPPG had advantages in long-term QOL over LADGBI in terms of C30 and STO22 questionnaire.