Neuro-Chirurgie · 2026
French translation and preliminary psychometric evaluation of the Meningioma Quality of Life questionnaire (MQOL-FR).
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Hudelist Benoit, Seneca Maimiti, Loy Jeanne, Waterhouse Lea, Angoustoures Flavie, Jonas Kara, Fazari Melissa, Trancart Bénédicte, Viviane Awassi M, Elia Angela, Huet-Mignaton Emmanuelle, Dufaure-Gare Isabelle, Cusimano Michael D, Pallud Johan
Аннотация
BACKGROUND: Disease-specific instruments to assess quality of life in meningioma patients are scarce, and no validated French meningioma-specific questionnaire is available. We translated the Meningioma Quality of Life questionnaire (MQOL) into French (MQOL-FR) and performed a preliminary psychometric evaluation focused on the total score.
METHODS: In this prospective study of adults with meningioma, MQOL was translated using the EORTC forward-backward procedure with expert-panel reconciliation. Patients completed MQOL-FR, Karnofsky Performance Status (KPS), Functional Assessment of Cancer Therapy-Brain (FACT-Br), and EQ-5D. Internal consistency (Cronbach's alpha), test-retest reliability (intraclass correlation coefficient (ICC), and convergent validity (Pearson correlations) were assessed using available complete data for each score.
RESULTS: Of 56 invited patients, 37 completed at least part of MQOL-FR. Across subscales, 32-36 patients contributed to internal consistency analyses, and 26 provided complete data for the MQOL total score (all scorable items completed; item 69 "non applicable/non-scored"). Cronbach's alpha for the total score was 0.88 (95%CI 0.75-0.95). Several subscales (symptoms, emotional, anxiety, functional well-being) showed acceptable reliability, whereas others (vitality, family, social, physical) were less robust. Thirteen patients completed the questionnaire twice; nine had complete paired total-score data. Test-retest reliability for the total score was excellent (ICC 0.93, 95%CI 0.71-0.98). Measurement error indices were SEM 3.8 points and MDC95 10.6 points (0-100 scale). The MQOL total score correlated strongly with the FACT-Br total score (r = 0.84).
CONCLUSIONS: MQOL-FR showed good internal consistency and excellent test-retest reliability for the total score, with encouraging convergent validity in this cohort. Subscale-level findings should be considered exploratory. Larger multicenter studies are needed to refine subscale performance, evaluate responsiveness to clinical change, and support broader validation in more representative samples.
METHODS: In this prospective study of adults with meningioma, MQOL was translated using the EORTC forward-backward procedure with expert-panel reconciliation. Patients completed MQOL-FR, Karnofsky Performance Status (KPS), Functional Assessment of Cancer Therapy-Brain (FACT-Br), and EQ-5D. Internal consistency (Cronbach's alpha), test-retest reliability (intraclass correlation coefficient (ICC), and convergent validity (Pearson correlations) were assessed using available complete data for each score.
RESULTS: Of 56 invited patients, 37 completed at least part of MQOL-FR. Across subscales, 32-36 patients contributed to internal consistency analyses, and 26 provided complete data for the MQOL total score (all scorable items completed; item 69 "non applicable/non-scored"). Cronbach's alpha for the total score was 0.88 (95%CI 0.75-0.95). Several subscales (symptoms, emotional, anxiety, functional well-being) showed acceptable reliability, whereas others (vitality, family, social, physical) were less robust. Thirteen patients completed the questionnaire twice; nine had complete paired total-score data. Test-retest reliability for the total score was excellent (ICC 0.93, 95%CI 0.71-0.98). Measurement error indices were SEM 3.8 points and MDC95 10.6 points (0-100 scale). The MQOL total score correlated strongly with the FACT-Br total score (r = 0.84).
CONCLUSIONS: MQOL-FR showed good internal consistency and excellent test-retest reliability for the total score, with encouraging convergent validity in this cohort. Subscale-level findings should be considered exploratory. Larger multicenter studies are needed to refine subscale performance, evaluate responsiveness to clinical change, and support broader validation in more representative samples.