Molecules (Basel, Switzerland) · 2026
Phytochemical Characterization of Freeze-Dried Stenocereus stellatus Seeds and Their Antihyperglycemic Activity in Experimental Prediabetes and Type 2 Diabetes.
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Oidor-Chan Víctor Hugo, Díaz de León-Sánchez Fernando, Valle-Mondragón Leonardo Del, Martínez-Memije Raúl, Torres-Narváez Juan Carlos, Cruz-Sosa Francisco, Patlán Mariana, Miranda Manuel, León-Martínez Melani, López-Olmos Victoria, Ibarra-Lara Luz, Castrejón-Téllez Vicente
Аннотация
BACKGROUND: Prediabetes and type 2 diabetes (T2D) are characterized by progressive impairment of glucose homeostasis. This study aimed to expand the phytochemical profile of freeze-dried Stenocereus stellatus (red tunillo) seeds and evaluate their antihyperglycemic activity in experimental models of prediabetes (PDB) and T2D.
RESULTS: Phytochemical screening and UPLC-QTOF-MSE revealed a chemically diverse profile. Six chromatographic features were putatively annotated on the basis of accurate mass, elemental composition, isotopic pattern, and high-energy data; the confidence of these annotations varied among features because authentic standards were not analyzed. Fourteen-day oral administration of freeze-dried seeds reduced blood glucose and improved glucose tolerance in prediabetic rats. In T2D rats, treatment reduced hyperglycemia and enhanced the glucose-lowering response to exogenous insulin, although the overall glucose excursion during the OGTT was not significantly improved.
METHODS: Female rats with PDB and male rats with T2D were fed freeze-dried S. stellatus seeds at 100 and 200 mg kg-1, respectively, for 14 consecutive days.
CONCLUSIONS: Freeze-dried S. stellatus seeds showed antihyperglycemic activity in both experimental models. Further quantitative, mechanistic, and long-term studies are required to define the contribution of individual metabolites and assess translational relevance.
RESULTS: Phytochemical screening and UPLC-QTOF-MSE revealed a chemically diverse profile. Six chromatographic features were putatively annotated on the basis of accurate mass, elemental composition, isotopic pattern, and high-energy data; the confidence of these annotations varied among features because authentic standards were not analyzed. Fourteen-day oral administration of freeze-dried seeds reduced blood glucose and improved glucose tolerance in prediabetic rats. In T2D rats, treatment reduced hyperglycemia and enhanced the glucose-lowering response to exogenous insulin, although the overall glucose excursion during the OGTT was not significantly improved.
METHODS: Female rats with PDB and male rats with T2D were fed freeze-dried S. stellatus seeds at 100 and 200 mg kg-1, respectively, for 14 consecutive days.
CONCLUSIONS: Freeze-dried S. stellatus seeds showed antihyperglycemic activity in both experimental models. Further quantitative, mechanistic, and long-term studies are required to define the contribution of individual metabolites and assess translational relevance.