Internal medicine (Tokyo, Japan) · 2017
Management of Pulmonary Mucormycosis Based on a Polymerase Chain Reaction (PCR) Diagnosis in Patients with Hematologic Malignancies: A Report of Four Cases.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Ino Kazuko, Nakase Kazunori, Nakamura Akiko, Nakamori Yoshiki, Sugawara Yumiko, Miyazaki Kana, Monma Fumihiko, Fujieda Atsushi, Sugimoto Yuka, Ohishi Kohshi, Masuya Masahiro, Katayama Naoyuki
Аннотация
Pulmonary mucormycosis (PM) is a life-threatening fungal infection in patients with hematologic malignancies, and early and accurate diagnostic modalities are urgently needed. We conducted a polymerase chain reaction (PCR) assay targeting these fungi in peripheral blood from four patients with hematologic malignancies who were strongly suspected of having PM. In these four patients, the Rhizopus species was identified in two patients, and the Cunninghamella and Absidia species in one each. Based on these molecular findings, all of the patients were successfully treated via targeted therapy with liposomal amphotericin B. In this report, a PCR analysis proved very useful for managing PM in patients with hematologic malignancies.