The American journal of tropical medicine and hygiene · 2023
Cutaneous and Visceral Leishmaniasis Caused by the Same Zymodeme of Leishmania donovani in Kerala, India.
СтатьяНазвание и аннотация: Перевод в очереди
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Saini Prasanta, Fathima Pananchikkaparambil Abdu, Aiswarya Rema Suresh, Ajithlal Puthenpurackal Madhavan, Rajesh Koothupalakkal Ravi, Simi Surendran Maheswari, Pradeep Kumar Narendran, Kumar Ashwani
Аннотация
The tribal population in and around the Western Ghats region of India is affected by both cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL) with typical clinical symptoms. In this study, we recorded and analyzed seven CL and three VL cases from this emerging belt. All the cases were found as autochthonous transmission. Multiple genetic markers (minicircle kinetoplast DNA polymerase chain reaction and restriction fragment length polymorphism of 3'untranslated region heat shock protein (HSP) 70, a larger segment of HSP 70, and 6-phosphogluconate dehydrogenase [PGDH] gene sequences) were used to identify and characterize the parasite. It was found that both clinical manifestations are caused by zymodeme MON-37 of Leishmania donovani. We have investigated the detailed entomological and epidemiological aspects of disease transmission. An abundant population of the proven vector Phlebotomus argentipes was observed in the study villages.