International journal of radiation oncology, biology, physics · 2026
Total-Body PET/CT Imaging After Proton Craniospinal Irradiation in Pediatric Patients: A Brief Report.
СтатьяНазвание и аннотация: Перевод в очереди
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Tang Hongmei, Xu Jiahui, Xiao Zhiping, Wu Yang, Zheng Renchao, Cheng Zhaoting, Song Shuang, Liu Fei, Zhu Yuankai, Zheng Hairong, Tao Zhen, Yuan Xianglin, Zhu Xiaohua
Аннотация
PURPOSE: This study aimed to report rapid off-line total-body positron emission tomography/computed tomography (PET/CT) imaging in pediatric patients after proton craniospinal irradiation (CSI), which enabled visualization of the entire craniospinal axis together with whole-body redistribution of proton-induced activity.
METHODS AND MATERIALS: Three pediatric patients with medulloblastoma or pineoblastoma underwent 60-minute dynamic, single-bed total-body PET/CT scans shortly after proton CSI using a rapid near-room transfer workflow. PET data were reconstructed into consecutive 5-minute frames and cumulative acquisitions to characterize regional temporal changes and acquisition duration-dependent image variability.
RESULTS: PET visualized activity along the full CSI axis and in extra-field major blood vessels and blood-rich organs. Regional PET signal decreased by 92.0%-94.8% in the cranial and spinal regions and by 89.4%-91.9% in the cardiac blood pool, liver, and spleen from the 0-5-minute to the 55-60-minute frame, reflecting the combined effects of physical decay and biological washout. The first 5 minutes of PET data depicted the major whole-body distribution pattern, whereas acquisitions of ∼20- 30 minutes substantially reduced regional image variability.
CONCLUSIONS: Rapid total-body PET/CT enabled single-bed visualization of the full craniospinal irradiation axis and quantitative characterization of whole-body temporal evolution after proton CSI.
METHODS AND MATERIALS: Three pediatric patients with medulloblastoma or pineoblastoma underwent 60-minute dynamic, single-bed total-body PET/CT scans shortly after proton CSI using a rapid near-room transfer workflow. PET data were reconstructed into consecutive 5-minute frames and cumulative acquisitions to characterize regional temporal changes and acquisition duration-dependent image variability.
RESULTS: PET visualized activity along the full CSI axis and in extra-field major blood vessels and blood-rich organs. Regional PET signal decreased by 92.0%-94.8% in the cranial and spinal regions and by 89.4%-91.9% in the cardiac blood pool, liver, and spleen from the 0-5-minute to the 55-60-minute frame, reflecting the combined effects of physical decay and biological washout. The first 5 minutes of PET data depicted the major whole-body distribution pattern, whereas acquisitions of ∼20- 30 minutes substantially reduced regional image variability.
CONCLUSIONS: Rapid total-body PET/CT enabled single-bed visualization of the full craniospinal irradiation axis and quantitative characterization of whole-body temporal evolution after proton CSI.