Journal of dental sciences · 2025
Anemia, hematinic deficiencies, and gastric parietal cell antibody positivity in oral lichen planus patients with or without hyperhomocysteinemia.
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Lee Yi-Pang, Jin Ying-Tai, Yu-Fong Chang Julia, Wang Yi-Ping, Sun Andy, Chiang Chun-Pin
Аннотация
BACKGROUND/PURPOSE: Our previous study found that 124 of 588 oral lichen planus (OLP) patients have hyperhomocysteinemia. This study assessed whether these 124 OLP patients with hyperhomocysteinemia (hyperhomocysteinemia/OLP patients) had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than 464 OLP patients without hyperhomocysteinemia (non-hyperhomocysteinemia/OLP patients) or 588 healthy control subjects.
MATERIALS AND METHODS: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 124 hyperhomocysteinemia/OLP patients, 464 non-hyperhomocysteinemia/OLP patients, and 588 healthy control subjects were measured and compared.
RESULTS: We found that 124 hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytosis, blood Hb and serum iron and vitamin B12 deficiencies, and serum GPCA positivity than 588 healthy control subjects (all P-values <0.001) or 464 non-hyperhomocysteinemia/OLP patients (all P-values <0.001). Anemia was found in 58 of 124 hyperhomocysteinemia/OLP patients and in 90 of 464 non-hyperhomocysteinemia/OLP patients. Normocytic anemia (22 cases), pernicious anemia (17 cases), and iron deficiency anemia (10 cases) were the three most common types of anemia in 124 hyperhomocysteinemia/OLP patients. Moreover, normocytic anemia (46 cases), iron deficiency anemia (22 cases), and thalassemia trait-induced anemia (18 cases) were the three most common types of anemia in 464 non-hyperhomocysteinemia/OLP patients. Moreover, the 124 hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytic and normocytic anemia than the 464 non-hyperhomocysteinemia/OLP patients.
CONCLUSION: Hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and serum GPCA positivity than healthy control subjects or non-hyperhomocysteinemia/OLP patients.
MATERIALS AND METHODS: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 124 hyperhomocysteinemia/OLP patients, 464 non-hyperhomocysteinemia/OLP patients, and 588 healthy control subjects were measured and compared.
RESULTS: We found that 124 hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytosis, blood Hb and serum iron and vitamin B12 deficiencies, and serum GPCA positivity than 588 healthy control subjects (all P-values <0.001) or 464 non-hyperhomocysteinemia/OLP patients (all P-values <0.001). Anemia was found in 58 of 124 hyperhomocysteinemia/OLP patients and in 90 of 464 non-hyperhomocysteinemia/OLP patients. Normocytic anemia (22 cases), pernicious anemia (17 cases), and iron deficiency anemia (10 cases) were the three most common types of anemia in 124 hyperhomocysteinemia/OLP patients. Moreover, normocytic anemia (46 cases), iron deficiency anemia (22 cases), and thalassemia trait-induced anemia (18 cases) were the three most common types of anemia in 464 non-hyperhomocysteinemia/OLP patients. Moreover, the 124 hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytic and normocytic anemia than the 464 non-hyperhomocysteinemia/OLP patients.
CONCLUSION: Hyperhomocysteinemia/OLP patients had significantly higher frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and serum GPCA positivity than healthy control subjects or non-hyperhomocysteinemia/OLP patients.