[Hypothalamic syndromes after the administration of toxic doses of drugs for terminating pregnancy].

Twenty-five women presented with primary injuries of the hypothalamic area and the hypothalamic syndrome that resulted from the intake of toxic doses of drugs (TDD) for inducing an abortion. The situation was simulated in mature rats. Experiments evidenced a predominant involvement of the hypothalamic area, vs. other portions of the brain. All the patients developed the vegetovascular form of the hypothalamic syndrome, combined with neuroendocrine and thermoregulation disturbances. TDD-induced increase of the vulnerability of the hypothalamus during pregnancy may be explained by structural and functional peculiarities of the female hypothalamus, by suppression of the dominant gestational functional integrating system formed during pregnancy and simultaneous failure of the principal performance system, the hypothalamus.