International multicentric validation of a novel T classification system for cancer of the nasal vestibule.
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van de Velde Lise J, Scheurleer W F Julius, Czerwinski Michal D, Verhoef Lia G, Ferrari Marco, De Berardinis Rita, Ansarin Mohssen, Soror Tamer, Motisi Laura, Meerwein Christian M, Fionda Bruno, Rampinelli Vittorio, Bignami Maurizio, Battaglia Paolo, Parrinello Giampiero, Chatelet Florian, Vinciguerra Alessandro, Takácsi-Nagy Zoltán, Patel Monik, Low Tsu-Hui Hubert, Mattiucci Gian Carlo, Saccardo Tommaso, Challapalli Amarnath, Chyrek Artur J, Juarez Marc, Rodriguez Villalba Silvia, Jonker Marianne A, Breimer Gerben E, de Bree Remco, Rijken Johannes A, Tagliaferri Luca, de Ridder Mischa, Bussu Francesco, Head & Neck and Skin (HNS) GEC-ESTRO Working Group.
Аннотация
METHODS: The four currently used classifications (UICC Sinonasal, UICC NMSC, Wang and Rome) were assessed in a retrospective multicenter cohort established within the Head & Neck and Skin Groupe Européen de Curiethérapie / European SocieTy for Radiotherapy & Oncology Working Group. Through multivariable disease-specific and recurrence-free survival analyses, it was evaluated which staging system was most valuable.
RESULTS: 609 CNV cases were retrieved from 21 tertiary care centers. Only the Wang and New Rome systems provided accurate prognostic stratification as they showed diminishing survival rates and increasing hazards of disease-specific death and disease recurrence with each successive T category. Compared to Wang, the New Rome system employs more objective criteria and, since it includes four T categories, it can easily be integrated with cN stage to obtain a specific clinical staging for the CNV, which has also resulted superior compared to the current UICC/AJCC systems in this study.
CONCLUSION: The New Rome classification exhibits a superior predictive and descriptive precision compared to the Wang and both UICC/AJCC systems. The New Rome's T category structure would allow an integration into the wider UICC/AJCC system once the nasal vestibule is acknowledged as a different subsite.