The Nigerian postgraduate medical journal · 2026
Serum Ceruloplasmin in Pre-eclampsia: A Case-Control Study in a Tertiary Health Centre in Southwest Nigeria.
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Chionuma Joy Onyinyechi, Adebara Olusegun Cosmos, Davies Nosimot Omolola, Makinde Oladimeji Abiodun, Rabiu Kabiru Afolarin
Аннотация
BACKGROUND: Pre-eclampsia is a pregnancy disorder linked with increased maternal and perinatal complications. An imbalance between free radical-induced lipid peroxidation and the antioxidant system may contribute to its pathogenesis.
AIMS: This study aimed to compare serum ceruloplasmin levels in women with pre-eclampsia and their normotensive counterparts and to assess its predictive value for disease severity.
SUBJECTS AND METHODS: A prospective case-control study was conducted involving 100 pregnant women diagnosed with pre-eclampsia, matched for age and parity against 100 healthy controls. Patients with pre-eclampsia were classified into mild (55) and severe (45) pre-eclampsia groups. Data on demographics, obstetric characteristics and outcomes were collected. Ceruloplasmin protein concentration was measured using a competitive enzyme-linked immunosorbent assay kit. Data analysis was performed using Stata Version 17. The reference range of serum ceruloplasmin for determining the risk of pre-eclampsia was from the 2.5 th to the 97.5 th percentile of the controls. The statistical significance level was set at P < 0.05.
RESULTS: The median interquartile range (IQR) serum ceruloplasmin levels were 21 mg/dL (IQR 17.5-23.8) in normotensive women, 35.5 mg/dl (IQR, 33.8-38.3) in mild pre-eclampsia, and 46.5 mg/dL (IQR, 42.5-49) in severe pre-eclampsia, with significant differences ( P = 0.001). The cut-off point for serum ceruloplasmin using Youden's index was 29 mg/dL. Ceruloplasmin exhibited 90.8% sensitivity, 95.6% specificity and positive and negative predictive values and accuracy of 96.1%, 89.6% and 92.3%, respectively, in pre-eclampsia.
CONCLUSION: Serum ceruloplasmin was elevated in pre-eclampsia, and the levels correlate with the severity of pre-eclampsia. The sensitivity and specificity observed in this study suggest that ceruloplasmin may be a potential marker for discriminating between normotensive pregnant women and those with pre-eclampsia. Elevated levels may be an indicator of severe disease.
AIMS: This study aimed to compare serum ceruloplasmin levels in women with pre-eclampsia and their normotensive counterparts and to assess its predictive value for disease severity.
SUBJECTS AND METHODS: A prospective case-control study was conducted involving 100 pregnant women diagnosed with pre-eclampsia, matched for age and parity against 100 healthy controls. Patients with pre-eclampsia were classified into mild (55) and severe (45) pre-eclampsia groups. Data on demographics, obstetric characteristics and outcomes were collected. Ceruloplasmin protein concentration was measured using a competitive enzyme-linked immunosorbent assay kit. Data analysis was performed using Stata Version 17. The reference range of serum ceruloplasmin for determining the risk of pre-eclampsia was from the 2.5 th to the 97.5 th percentile of the controls. The statistical significance level was set at P < 0.05.
RESULTS: The median interquartile range (IQR) serum ceruloplasmin levels were 21 mg/dL (IQR 17.5-23.8) in normotensive women, 35.5 mg/dl (IQR, 33.8-38.3) in mild pre-eclampsia, and 46.5 mg/dL (IQR, 42.5-49) in severe pre-eclampsia, with significant differences ( P = 0.001). The cut-off point for serum ceruloplasmin using Youden's index was 29 mg/dL. Ceruloplasmin exhibited 90.8% sensitivity, 95.6% specificity and positive and negative predictive values and accuracy of 96.1%, 89.6% and 92.3%, respectively, in pre-eclampsia.
CONCLUSION: Serum ceruloplasmin was elevated in pre-eclampsia, and the levels correlate with the severity of pre-eclampsia. The sensitivity and specificity observed in this study suggest that ceruloplasmin may be a potential marker for discriminating between normotensive pregnant women and those with pre-eclampsia. Elevated levels may be an indicator of severe disease.