Germ Cell Neoplasia In situ in Undescended Testis: A Myth or Reality?

BACKGROUND

Untreated cryptorchid testes are in risk of intratubular germ cell neoplasia and subsequently may give rise to invasive germ cell tumors.

MATERIALS AND

METHODS

Tissue samples were obtained from patients undergoing orchidectomy or orchiopexy and were subjected to routine histopathological and immunohistochemical examinations.

RESULTS

Forty-three patients were enrolled in this study out of which 30 samples were collected. The mean age of patients was 9.16 years. One case (6.7%) showed positivity of the germ cell neoplasia with anto placental alkaline phosphatase and Anto CD-117 positive. Other histopathological findings such as fibrocollagenous tissue and Leydig cell hyperplasia were reported.

CONCLUSION

Early surgical management is of importance for a better outcome in cases of undescended testes.