C-reactive protein as a predictor of complicated acute cholecystitis: A cohort study.

INTRODUCTION

The Tokyo Guidelines for the severity classification of acute cholecystitis (AC) include leukocytosis as a severity classifier, without considering C-reactive protein (CRP). Our aim was to determine which of the two variables has a greater predictive capacity for local complications in AC (LCAC).

MATERIAL AND

METHODS

A retrospective single-center study was conducted on patients that underwent emergency cholecystectomy within the time frame of June 2022 and December 2023. The variables associated with LCAC were analyzed and an ROC analysis was carried out.

RESULTS

The multivariate analysis of 145 patients identified the following associations with LCAC: CRP (p < 0.001; OR 11.8), AUC of 0.88 (p = 0.029), and cutoff point of 4 mg/dl (88% sensitivity, 71% specificity); leukocytosis (p < 0.031; OR 5), AUC of 0.81(p = 0.037), and cutoff point of 11.09 x 109/l (78% sensitivity, 70% specificity).

CONCLUSIONS

CRP may have a higher predictive capacity for LCAC than leukocytosis.