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DOI 10.1016/j.rmed.2024.107883

Медицинская библиотека · Respiratory medicine · 2024

Factors influencing the prescription of add-on long-acting muscarinic antagonists in real-world asthma management: Insights from a national registry.

Gemicioglu Bilun, Gokmen Derya, Can Ali, Sevinc Can, Oguzulgen Ipek Kivilcim, Soyyigit Sadan, Yakut Tugce, Havlucu Yavuz, Aydin Omur, Buhari Gozde Koycu, Sozener Zeynep Celebi, Bulut Ismet, Beyaz Sengul, Orcen Cihan, Ozdemir Secil Kepil, Keren Metin, Damadoglu Ebru, Kalpaklioglu Ayse Fusun, Baccioglu Ayse, Yalim Sumeyra Alan, Yilmaz Insu, Kalkan Ilkay Koca, Uysal Mehmet Atilla, Ozgun Niksarlioglu Elif Yelda, Kalyoncu Ali Fuat, Karakaya Gul, Erbay Muge, Nayci Sibel, Tepetam Fatma Merve, Gelincik Asli, Dirol Hulya, Goksel Ozlem, Karaoglanoglu Selen, Erkekol Ferda Oner, Isik Sacide Rana, Yildiz Fusun, Yavuz Yasemin, Karadogan Dilek, Bozkurt Nurgul, Seker Ummuhan, Basyigit Ilknur, Baris Serap Argun, Ucar Elif Yilmazel, Erdogan Tuba, Polatli Mehmet, Ediger Dane, Gunaydin Fatma Esra, Turk Murat, Pur Leyla, Katran Zeynep Yegin, Sekibag Yonca, Aykac Enes Furkan, Mungan Dilsad, Gul Ozcan, Cengiz Ali, Akkurt Bulent, Ozden Seyma, Demir Semra, Unal Derya, Aslan Ayse Feyza, Gumusburun Reyhan, Bogatekin Gulhan, Akten Hatice Serpil, Inan Sinem, Erdinc Munevver, Ogus Aliye Candan, Kavas Murat, Yulug Demet Polat, Cakmak Mehmet Erdem, Kaya Saltuk Bugra, Alpagat Gulistan, Ozgur Eylem Sercan, Uzun Oguz, Gulen Sule Tas, Pekbak Gulseren, Kizilirmak Deniz, Donmez Halil, Arslan Bahar, Cetin Gulden Pacaci, Kara Bilge Yilmaz, Dursun Adile Berna, Karakis Gulden Pasaoglu, Kendirlinan Resat, Ozturk Ayse Bilge, Simsek Gokcen Omeroglu, Abadoglu Oznur, Cerci Pamir, Yucel Taskin, Yorulmaz Irfan, Tezcaner Zahide Ciler, Tatar Emel Cadalli, Suslu Ahmet Emre, Ozer Serdar, Dursun Engin, Yorgancioglu Arzu, Çelik Gülfem Elif

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Current guidelines recommend adding long-acting muscarinic antagonists (LAMAs) in patients with uncontrolled asthma, despite the use of moderate to high doses of inhaled steroid-long-acting beta agonists (ICS/LABA). This study aims to analyze the factors related to the prescription of add-on LAMA in clinical practice for asthma patients, shedding light on physicians' preferences. This study included adult asthma patients on add-on LAMA and ICS/LABA monitored for at least one year in a national registry comprising 2053 asthmatics. Patients' characteristics and disease profiles were analyzed to identify factors associated with the prescription of add-on LAMA across the entire cohort. A comparative analysis was performed among three groups: MART (ICS/formoterol as a maintenance and reliever therapy) plus LAMA, Conventional (ICS/LABA as a maintenance and short-acting beta agonist as reliever) plus LAMA and Triple (ICS/LABA/LAMA single inhaler). LAMAs were added to ICS/LABA in 11.7 % of patients in the national registry. Logistic regression analysis revealed that older age, low FEV1 (%), Asthma Control Test (ACT) scores less than 20, and severe exacerbation were the main factors influencing the initiation of LAMA in our registry. However, demographic characteristics of asthma, control status, pulmonary function test results were similar among the three groups of LAMA users (p > 0.05). Physicians used LAMAs without phenotyping based on allergic status or eosinophil levels (p > 0.05). Mepolizumab was added after LAMA in all patients, while omalizumab was initiated before LAMA in 16.9 % of the patients receiving LAMA along with biologics. Add-on LAMAs were predominantly prescribed for older, uncontrolled, and exacerbated asthma patients with low FEV1.

Для цитирования: Gemicioglu Bilun, Gokmen Derya, Can Ali, Sevinc Can, Oguzulgen Ipek Kivilcim, Soyyigit Sadan, Yakut Tugce, Havlucu Yavuz, Aydin Omur, Buhari Gozde Koycu, Sozener Zeynep Celebi, Bulut Ismet, Beyaz Sengul, Orcen Cihan, Ozdemir Secil Kepil, Keren Metin, Damadoglu Ebru, Kalpaklioglu Ayse Fusun, Baccioglu Ayse, Yalim Sumeyra Alan, Yilmaz Insu, Kalkan Ilkay Koca, Uysal Mehmet Atilla, Ozgun Niksarlioglu Elif Yelda, Kalyoncu Ali Fuat, Karakaya Gul, Erbay Muge, Nayci Sibel, Tepetam Fatma Merve, Gelincik Asli, Dirol Hulya, Goksel Ozlem, Karaoglanoglu Selen, Erkekol Ferda Oner, Isik Sacide Rana, Yildiz Fusun, Yavuz Yasemin, Karadogan Dilek, Bozkurt Nurgul, Seker Ummuhan, Basyigit Ilknur, Baris Serap Argun, Ucar Elif Yilmazel, Erdogan Tuba, Polatli Mehmet, Ediger Dane, Gunaydin Fatma Esra, Turk Murat, Pur Leyla, Katran Zeynep Yegin, Sekibag Yonca, Aykac Enes Furkan, Mungan Dilsad, Gul Ozcan, Cengiz Ali, Akkurt Bulent, Ozden Seyma, Demir Semra, Unal Derya, Aslan Ayse Feyza, Gumusburun Reyhan, Bogatekin Gulhan, Akten Hatice Serpil, Inan Sinem, Erdinc Munevver, Ogus Aliye Candan, Kavas Murat, Yulug Demet Polat, Cakmak Mehmet Erdem, Kaya Saltuk Bugra, Alpagat Gulistan, Ozgur Eylem Sercan, Uzun Oguz, Gulen Sule Tas, Pekbak Gulseren, Kizilirmak Deniz, Donmez Halil, Arslan Bahar, Cetin Gulden Pacaci, Kara Bilge Yilmaz, Dursun Adile Berna, Karakis Gulden Pasaoglu, Kendirlinan Resat, Ozturk Ayse Bilge, Simsek Gokcen Omeroglu, Abadoglu Oznur, Cerci Pamir, Yucel Taskin, Yorulmaz Irfan, Tezcaner Zahide Ciler, Tatar Emel Cadalli, Suslu Ahmet Emre, Ozer Serdar, Dursun Engin, Yorgancioglu Arzu, Çelik Gülfem Elif. Factors influencing the prescription of add-on long-acting muscarinic antagonists in real-world asthma management: Insights from a national registry.. Respiratory medicine. 2024. DOI: 10.1016/j.rmed.2024.107883.

Предметные рубрики MeSH

HumansAsthmaMaleFemaleMuscarinic AntagonistsRegistriesMiddle AgedAdultAdministration, InhalationDrug Therapy, CombinationAnti-Asthmatic AgentsAgedAdrenal Cortex HormonesFormoterol FumaratePractice Patterns, Physicians'Forced Expiratory Volume
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