Long COVID After Acquisition of the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During Pregnancy Compared With Outside of Pregnancy.
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Metz Torri D, Reeder Harrison T, Clifton Rebecca G, Flaherman Valerie, Aragon Leyna V, Baucom Leah Castro, Beamon Carmen J, Braverman Alexis, Brown Jeanette, Carmilani Megan, Cao Tingyi, Chang Ann, Costantine Maged M, Dionne Jodie A, Gibson Kelly S, Gross Rachel S, Guerreros Estefania, Habli Mounira, Hess Rachel, Hillier Leah, Hodder Sally, Hoffman M Camille, Hoffman Matthew K, Huang Weixing, Hughes Brenna L, Jia Xiaolin, Kale Minal, Katz Stuart D, Laleau Victoria, Mendez-Figueroa Hector, McComsey Grace A, Ofotokun Igho, Okumura Megumi J, Pacheco Luis D, Palatnik Anna, Palomares Kristy T S, Parry Samuel, Pettker Christian M, Plunkett Beth A, Poppas Athena, Ramsey Patrick, Reddy Uma M, Rouse Dwight J, Saade George R, Sandoval Grecio J, Sciurba Frank, Simhan Hyagriv N, Skupski Daniel W, Sowles Amber, Thorp John M, Tita Alan T N, Wiegand Samantha, Weiner Steven J, Yee Lynn M, Horwitz Leora I, Foulkes Andrea S, Jacoby Vanessa L, NIH RECOVER (Researching COVID to Enhance Recovery) Consortium
Аннотация
METHODS: We conducted a multicenter observational cohort study at 79 NIH RECOVER (Researching COVID to Enhance Recovery) sites. Individuals assigned female at birth aged 18-45 years with an index (first) SARS-CoV-2 infection on or after December 1, 2021, were included. The exposure was pregnancy (any gestational age) at the time of index SARS-CoV-2 infection. The primary outcome was long COVID 6 months after index infection , defined as RECOVER-Adult Long COVID Research Index score 11 or higher based on a detailed symptom survey. To account for confounding and differential selection between participants who were pregnant and not pregnant at infection, propensity score-matching methods were used to balance the groups on variables potentially associated with both pregnancy status and long COVID.
RESULTS: Overall 2,423 participants were included; 580 (23.9%) were pregnant at index SARS-CoV-2 infection. The median age at infection was 33 years (interquartile range 28-38 years), and 2,131 of participants (90.0%) with known vaccination status were vaccinated. After propensity score matching, the adjusted long COVID prevalence estimates 6 months after index infection were 10.2% (95% CI, 6.2-14.3%) among those pregnant at infection and 10.6% (95% CI, 8.8-12.4%) among those not pregnant at infection. Pregnancy was not associated with a difference in adjusted risk of long COVID (adjusted risk ratio 0.96, 95% CI, 0.63-1.48).
CONCLUSION: Acquisition of SARS-CoV-2 during pregnancy was not associated with a differential risk of long COVID at 6 months compared with similar-aged individuals who acquired SARS-CoV-2 outside of pregnancy.