Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2026
Clinical and Autoantibody Profile of Inflammatory Myopathies in a Mexican Cohort: A Descriptive Study.
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Sanchez-Medieta Grisel G, Delgado-Ayala Selene M, Arana-Guajardo Ana Cecilia, Villareal-Alarcon Miguel A, Galarza-Delgado Dionicio A, Gil-Flores Lourdes, Vega-Morales David
Аннотация
BACKGROUND: Inflammatory myopathies (IIMs) are a group of autoimmune diseases characterized by muscle inflammation and systemic features. Although autoantibody profiling has improved disease classification, regional data from Latin America remain limited.
OBJECTIVE: To describe the clinical and serological characteristics of a Mexican cohort.
METHODS: We conducted a cross-sectional study of adult patients who met the 2017 EULAR/ACR criteria for IIMs at a tertiary rheumatology clinic in Monterrey, Mexico, from 2015 to 2019. We interviewed patients, reviewed medical records, and performed a myositis autoantibody immunoblot panel and summarized clinical features by autoantibody positivity.
RESULTS: Seventy patients were included (74.3% female, mean age 44 y). Dermatomyositis was the most frequent clinical subtype (68.6%). The most common clinical features included proximal muscle weakness, Gottron's papules, and articular involvement. The most prevalent autoantibodies were anti-Ro52 (34.3%), anti-Mi2a (24.3%), and anti-PL7 (14.3%). Less common antibodies included anti-MDA5, anti-SRP, anti-TIF1γ, anti-NXP2, anti-Ku, and others, with frequencies ranging from 1.4% to 12.9%.
CONCLUSIONS: This study provides a detailed clinical-serological characterization of IIMs in a Mexican cohort. Our findings reinforce recognized clinico-serological phenotypes and suggest regional patterns, including the high prevalence of anti-Ro52. These results underscore the need for broader autoantibody testing and contribute to the understanding of IIM heterogeneity in underrepresented populations.
OBJECTIVE: To describe the clinical and serological characteristics of a Mexican cohort.
METHODS: We conducted a cross-sectional study of adult patients who met the 2017 EULAR/ACR criteria for IIMs at a tertiary rheumatology clinic in Monterrey, Mexico, from 2015 to 2019. We interviewed patients, reviewed medical records, and performed a myositis autoantibody immunoblot panel and summarized clinical features by autoantibody positivity.
RESULTS: Seventy patients were included (74.3% female, mean age 44 y). Dermatomyositis was the most frequent clinical subtype (68.6%). The most common clinical features included proximal muscle weakness, Gottron's papules, and articular involvement. The most prevalent autoantibodies were anti-Ro52 (34.3%), anti-Mi2a (24.3%), and anti-PL7 (14.3%). Less common antibodies included anti-MDA5, anti-SRP, anti-TIF1γ, anti-NXP2, anti-Ku, and others, with frequencies ranging from 1.4% to 12.9%.
CONCLUSIONS: This study provides a detailed clinical-serological characterization of IIMs in a Mexican cohort. Our findings reinforce recognized clinico-serological phenotypes and suggest regional patterns, including the high prevalence of anti-Ro52. These results underscore the need for broader autoantibody testing and contribute to the understanding of IIM heterogeneity in underrepresented populations.