Successful management of acute interstitial nephritis in two cases of disseminated tuberculosis.

Acute interstitial nephritis (AIN) is characterized by an inflammatory infiltrate in the kidney interstitium and a decline in the creatinine clearance. Medications used for the treatment of tuberculosis have been implicated in the development of AIN, but there is limited data on how to manage AIN in this setting and which medications and dosages should be used to treat tuberculosis once AIN occurs. We describe two cases of AIN in the setting of disseminated tuberculosis in which AIN was successfully managed. It is recommended that Infectious Diseases and Nephrology be involved early in the care of these patients, preferably in an inpatient setting in order to expedite diagnosis and management.