Human precipitins against a micro-organism (Candida albicans) demonstrated by means of quantitative immunoelectrophoresis.

By means of the antigen–antibody crossed electrophoresis of Laurell twenty-two different Candida albicans precipitins were demonstrated in a serum from a 56-year-old woman suffering from idiopathic hypoparathyroidism and chronic candidiasis. This precipitin response is remarkably strong, but a detailed evaluation of the finding must await further investigations. It is mentioned how the human precipitins may be quantitated and the titres expressed in arbitrary rabbit precipitin units. The antigen–antibody crossed electrophoresis may be useful in other infections, and possibly in certain autoimmune diseases, in order quantitatively to screen patient sera for a multitude of precipitins without purification of the individual antigens.