The Journal of infection · 2011
Diagnostic performance of T-SPOT.TB for extrapulmonary tuberculosis according to the site of infection.
СтатьяНаблюдательное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Cho Oh-Hyun, Park Ki-Ho, Kim Sun-Mi, Park Su-Jin, Moon Song Mi, Chong Yong Phil, Sung Heungsup, Kim Mi-Na, Jeong Jin-Yong, Lee Sang-Oh, Choi Sang-Ho, Woo Jun Hee, Kim Yang Soo, Kim Sung-Han
Аннотация
BACKGROUND: The clinical manifestations of extrapulmonary tuberculosis (E-TB) vary according to site of disease, so we tested the hypothesis that IFN-γ producing T-cell responses also vary in parallel. Therefore we conducted a prospective, blinded, observational study to evaluate the diagnostic performance of blood T-SPOT.TB according to the various sites of E-TB.
METHODS: From April 2008 to August 2010, all patients with suspected E-TB were enrolled at a tertiary hospital in an intermediate TB-burden country. Final diagnosis in patients with suspected E-TB was classified by clinical category.
RESULTS: A total of 368 patients with suspected E-TB were enrolled; 196 (53%) were classified as having TB, including 119 (32%) with confirmed TB, 34 (9%) probable TB, and 43 (12%) possible TB; the remaining 172 (47%) were classified as not having TB. After excluding patients with possible TB, the T-SPOT.TB was more sensitive in patients with chronic forms of E-TB such as lymph node or osteoarticular TB (93%, 95% CI 83%-97%) than in patients with acute forms of E-TB such as TB meningitis or miliary TB (79%, 95% CI 66%-87%, P = 0.03).
CONCLUSIONS: The diagnostic performance of the blood T-SPOT.TB differs among patients with various clinical manifestations of E-TB.
METHODS: From April 2008 to August 2010, all patients with suspected E-TB were enrolled at a tertiary hospital in an intermediate TB-burden country. Final diagnosis in patients with suspected E-TB was classified by clinical category.
RESULTS: A total of 368 patients with suspected E-TB were enrolled; 196 (53%) were classified as having TB, including 119 (32%) with confirmed TB, 34 (9%) probable TB, and 43 (12%) possible TB; the remaining 172 (47%) were classified as not having TB. After excluding patients with possible TB, the T-SPOT.TB was more sensitive in patients with chronic forms of E-TB such as lymph node or osteoarticular TB (93%, 95% CI 83%-97%) than in patients with acute forms of E-TB such as TB meningitis or miliary TB (79%, 95% CI 66%-87%, P = 0.03).
CONCLUSIONS: The diagnostic performance of the blood T-SPOT.TB differs among patients with various clinical manifestations of E-TB.