European journal of internal medicine · 2013
Immunological profiles determine neurological involvement in Sjögren's syndrome.
СтатьяНазвание и аннотация: Перевод в очереди
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Jamilloux Yvan, Magy Laurent, Hurtevent Jean-François, Gondran Guillaume, de Seze Jérôme, Launay David, Ly Kim H, Lambert Marc, Hachulla Eric, Hatron Pierre-Yves, Vidal Elisabeth, Fauchais Anne-Laure
Аннотация
BACKGROUND: Up to 68% of patients with primary Sjögren's syndrome (pSS) undergo neurological complications, and evidence for distinct immunological subgroups is emerging. We sought to determine systemic and immunological profiles associated with neurological manifestations.
METHODS: 420 patients fulfilling the 2002 American-European pSS criteria were retrospectively analyzed. Neurological manifestations were diagnosed through clinical, biological, electrophysiological, and imaging findings. Biographical, clinical, and laboratory data were compared.
RESULTS: Within 93 (22%) patients with neurological manifestations, peripheral and central nervous systems were involved in 66% and 44%, respectively. Raynaud's phenomenon, cutaneous vasculitis, renal involvement, and cryoglobulinemia were associated with sensorimotor neuropathy and mononeuritis multiplex (p<0.05). Conversely, pure sensory neuropathy occurred without extraglandular manifestation, and without anti-Ro/SSA antibodies (p<0.05). All neurological manifestations were associated with increased use of corticosteroids and immunosuppressive drugs (p<0.05).
CONCLUSIONS: In pSS, patients with sensorimotor neuropathies and pure sensory neuropathies have distinct extraglandular and immunological profiles.
METHODS: 420 patients fulfilling the 2002 American-European pSS criteria were retrospectively analyzed. Neurological manifestations were diagnosed through clinical, biological, electrophysiological, and imaging findings. Biographical, clinical, and laboratory data were compared.
RESULTS: Within 93 (22%) patients with neurological manifestations, peripheral and central nervous systems were involved in 66% and 44%, respectively. Raynaud's phenomenon, cutaneous vasculitis, renal involvement, and cryoglobulinemia were associated with sensorimotor neuropathy and mononeuritis multiplex (p<0.05). Conversely, pure sensory neuropathy occurred without extraglandular manifestation, and without anti-Ro/SSA antibodies (p<0.05). All neurological manifestations were associated with increased use of corticosteroids and immunosuppressive drugs (p<0.05).
CONCLUSIONS: In pSS, patients with sensorimotor neuropathies and pure sensory neuropathies have distinct extraglandular and immunological profiles.
Предметные рубрики MeSH
AdultAgedAntibodies, AntinuclearCentral Nervous System DiseasesCohort StudiesCryoglobulinemiaFemaleHumansKidney DiseasesMaleMiddle AgedMononeuropathiesMotor Neuron DiseasePeripheral Nervous System DiseasesPolyradiculopathyProportional Hazards ModelsRaynaud DiseaseRetrospective StudiesRheumatoid FactorSjogren's SyndromeSomatosensory DisordersVasculitis