Preoperative Metabolic Risk Factors and Outcomes in Living Donor Liver Transplant in HBV Recipients.

Objective

Additional preoperative risk factors may influence the prognosis of patients diagnosed with HBV. This study aims to compare the effects of cirrhosis patients with HBV with and without risk factors on post-transplant follow-ups and postoperative complications. Materials and Method: The study included patients with HBV who underwent living donor liver transplantation (LDLT) at Demiroğlu Bilim University, Şişli Liver Transplant Center, Istanbul, Türkiye, between 2004 and 2019. The data from 319 patients were retrospectively analyzed. Those without preoperative risk factors were classified as group 1 (n = 214), and those with risk factors were classified as group 2 (n = 105). These patients were compared in terms of complications during their postoperative follow-up. The Student's t-test, ANOVA test, Mann-Whitney U test, Kruskal-Wallis test, chi-squared test, and Fisher's exact test were used, and p < 0.05 was considered statistically significant.

Results

When group 1 and group 2 were compared in terms of postoperative mortality, infections, bleeding complications, and biliary system complications, no statistically significant difference was found [(8.87% vs. 9.52% p = 0.62), (28.80% vs. 20.24%, p = 0.95), (6.10% vs. 8.70%, p = 0.35), (12.7% vs. 9.60% p = 0.19, respectively)]. Although bleeding complications were numerically found more frequent in patients with obesity, this difference did not reach statistical significance (23.02% vs. 6.10% p = 0.08).

Conclusions

Obesity was not significantly associated with postoperative complications and may be influenced by accompanying comorbidities.