Mediators of inflammation · 2006
Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/or NSAIDs hypersensitivity.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Pacor Maria Luisa, Di Lorenzo Gabriele, Mansueto Pasquale, Martinelli Nicola, Esposito-Pellitteri Maria, Pradella Paola, Uxa Laura, Di Fede Gaetana, Rini GiovamBattista, Corrocher Roberto
Аннотация
BACKGROUND: HLA genes play a role in the predisposition of several diseases. The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU).
METHODS: 69 patients with AICU, and 200 healthy subjects.
RESULTS: Subjects with HLA-B44 and HLA-Cw5 antigens were more represented in patients with AICU than in control group. Subjects with HLA-A11, HLA-B13, HLACw4, and HLA-Cw7 antigen were more represented in control group than in patients with AICU. Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lower risk of AICU, whereas carriers of HLA-B44 phenotype had a higher risk of AICU. No differences were found between patients and controls as regards to HLA-DRB1* genotype.
CONCLUSIONS: We observed an association between some HLA class-I antigens and AICU. To the best of our knowledge this is the first description of such association.
METHODS: 69 patients with AICU, and 200 healthy subjects.
RESULTS: Subjects with HLA-B44 and HLA-Cw5 antigens were more represented in patients with AICU than in control group. Subjects with HLA-A11, HLA-B13, HLACw4, and HLA-Cw7 antigen were more represented in control group than in patients with AICU. Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lower risk of AICU, whereas carriers of HLA-B44 phenotype had a higher risk of AICU. No differences were found between patients and controls as regards to HLA-DRB1* genotype.
CONCLUSIONS: We observed an association between some HLA class-I antigens and AICU. To the best of our knowledge this is the first description of such association.