Multicenter retrospective analysis of primary small intestinal lymphoma in Japan.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Kitamura Masafumi, Yano Tomonori, Oka Shiro, Torisu Takehiro, Shiomi Akio, Hotta Kinichi, Ishida Fumio, Kudo Shin-Ei, Yamada Takeshi, Mitsui Keigo, Okajima Masazumi, Uraoka Toshio, Nozawa Hiroaki, Kurahara Koichi, Ikematsu Hiroaki, Ito Masaaki, Takahashi Keiichi, Saito Shoichi, Ueno Masashi, Yamaguchi Shigeki, Fukai Yasumori, Kuwai Toshio, Nagata Shinji, Ajioka Yoichi, Kato Tomohiro, Takeuchi Yoji, Hashiguchi Yojiro, Ohmiya Naoki, Yamano Tomoki, Itabashi Michio, Sunami Eiji, Otsuji Eigo, Kanemitsu Yukihide, Takamaru Hiroyuki, Matsumoto Takayuki, Sugai Tamotsu, Kawai Masaya, Yao Takashi, Takayama Tetsuji, Shinto Eiji, Ohtsuka Kazuo, Kinugasa Yusuke, Sugihara Kenichi, Esaki Motohiro, Kato Takeshi, Togashi Kazutomo, Akagi Yoshito, Kashida Hiroshi, Horimatsu Takahiro, Saitoh Yusuke, Yamada Kazutaka, Koda Keiji, Hamada Madoka, Komori Koji, Toyoshima Akira, Tanaka Shinji, Yamamoto Hironori
Аннотация
METHODS: We conducted a nationwide multicenter retrospective study of 686 patients diagnosed with PSIL between January 2008 and December 2017 at 44 institutions in Japan. Clinical characteristics, histological subtypes, and overall survival were analyzed.
RESULTS: B-cell lymphoma was the predominant immunophenotype (n = 623, 91%), whereas T-cell lymphoma was uncommon (n = 50, 7%). Diffuse large B-cell lymphoma (DLBCL) was the most frequent histological subtype (n = 330, 48%), followed by follicular lymphoma (FL) (n = 224, 33%). Compared with other B-cell lymphomas, FL was more common in women and more frequently involved the jejunum (P < 0.001). The 5-year overall survival rate was significantly higher in patients with B-cell lymphoma than in those with T-cell lymphoma (81% vs. 23%, P < 0.001). Multivariate Cox regression analysis identified age > 60 years and T-cell lymphoma as independent adverse prognostic factors, whereas FL was an independent predictor of favorable overall survival.
CONCLUSIONS: This nationwide multicenter analysis delineates the clinicopathological features and survival outcomes of PSIL in Japan. FL represents the second most common subtype after DLBCL and is associated with a favorable prognosis among PSIL subtypes.