The Journal of surgical research · 2025
Angiopoietin-like Protein 2 Expression Is Associated With Host Wasting-Related Poor Prognosis in Colorectal Cancer.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Horino Taichi, Horiguchi Haruki, Yumoto Shinsei, Kadomatsu Tsuyoshi, Ohuchi Mayuko, Ogawa Katsuhiro, Hiyoshi Yukiharu, Miyamoto Yuji, Iwatsuki Masaaki, Oike Yuichi
Аннотация
INTRODUCTION: Tumor-induced host wasting marked by malnutrition, systemic inflammation, or altered body composition is associated with poor prognosis in cancer patients. Tumor cell-derived angiopoietin-like protein 2 (ANGPTL2) reportedly functions as a tumor promoter in some cancer contexts. This study aims to assess whether ANGPTL2 expression in tumor cells is associated with host wasting in patients with colorectal cancer.
METHODS: We retrospectively enrolled 88 patients with all-stage colorectal cancer who underwent surgical resection of the primary tumor between January 2017 and December 2017 in a single institution. Based on immunohistochemistry staining, we assessed ANGPTL2 expression in tumor cells in paraffin-embedded tumor samples from resected specimens. The association of the ANGPTL2 expression with clinicopathological factors, biomarkers of host wasting, and survival were analyzed.
RESULTS: Host wasting was associated with significantly high other causes-mortality rates in ANGPTL2-high patients (P = 0.0261) but not in ANGPTL2-low patients (P = 0.4719), suggesting that ANGPTL2 expression in colorectal cancer cells is associated with host wasting-related poor prognosis. Furthermore, ANGPTL2 expression in tumor cells was correlated with the advanced lung cancer inflammation index, which is a biomarker of host wasting (ρ = -0.3119, P = 0.0031).
CONCLUSIONS: ANGPTL2 is associated with host wasting-related poor prognosis through its association with systemic inflammation in patients with colorectal cancer. These findings overall provide novel insight into ANGPTL2 function and illustrate the essential role of tumor-host interactions in the prognosis of cancer survivors.
METHODS: We retrospectively enrolled 88 patients with all-stage colorectal cancer who underwent surgical resection of the primary tumor between January 2017 and December 2017 in a single institution. Based on immunohistochemistry staining, we assessed ANGPTL2 expression in tumor cells in paraffin-embedded tumor samples from resected specimens. The association of the ANGPTL2 expression with clinicopathological factors, biomarkers of host wasting, and survival were analyzed.
RESULTS: Host wasting was associated with significantly high other causes-mortality rates in ANGPTL2-high patients (P = 0.0261) but not in ANGPTL2-low patients (P = 0.4719), suggesting that ANGPTL2 expression in colorectal cancer cells is associated with host wasting-related poor prognosis. Furthermore, ANGPTL2 expression in tumor cells was correlated with the advanced lung cancer inflammation index, which is a biomarker of host wasting (ρ = -0.3119, P = 0.0031).
CONCLUSIONS: ANGPTL2 is associated with host wasting-related poor prognosis through its association with systemic inflammation in patients with colorectal cancer. These findings overall provide novel insight into ANGPTL2 function and illustrate the essential role of tumor-host interactions in the prognosis of cancer survivors.