Journal of medical biochemistry · 2026
Phospholipid transfer protein: The link between lipid metabolism and inflammation in healthy pregnancy and pregnancy with cardiometabolic complications.
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Stanković Marko, Munjaš Jelena, Derikonjić Minja, Željković Aleksandra, Vekić Jelena, Antonić Tamara, Ardalić Daniela, Miljković-Trailović Milica, Šarić-Matutinović Marija, Gojković Tamara, Jovičić Snežana, Miković Željko, Stefanović Aleksandra
Аннотация
BACKGROUND: Phospholipid transfer protein (PLTP) regulates high-density lipoprotein (HDL) remodelling by transferring cholesterol and phospholipids and affecting particle size and function. Pregnancy alters lipid metabolism, but the adaptation of PLTP to pregnancy remains poorly understood. This study investigated longitudinal changes in PLTP gene expression and concentration during healthy pregnancy and pregnancy with cardiometabolic complications, and their associations with maternal lipid metabolism and inflammatory status.
METHODS: We followed 84 healthy and 20 pregnant women who developed gestational diabetes mellitus and hypertensive disorders during pregnancy. PLTP gene expression, PLTP concentration, advanced lipid profile parameters, and inflammatory status were analysed throughout the trimesters.
METHODS: We followed 84 healthy and 20 pregnant women who developed gestational diabetes mellitus and hypertensive disorders during pregnancy. PLTP gene expression, PLTP concentration, advanced lipid profile parameters, and inflammatory status were analysed throughout the trimesters.