Lu-177 DOTATATE Therapy in a Treatment Naive Metastatic NET Pineal Gland With Drop Metastasis to Spinal Cord: A Great Leap Forward in Oncology.

Neuroendocrine tumors (NETs) are a heterogeneous group of tumors, which are usually indolent with metastatic disease at the initial presentation in most clinical situations. Intramedullary spinal cord metastasis (ICSM) is usually rare in the case of neuroendocrine tumors. Peptide receptor radionuclide therapy (PRRT) with Lu-177 DOTATATE has been in use for treatment of metastatic NETs for a long time. Here, the authors present favorable response to PRRT in a treatment-naive patient with metastatic NET of the pineal gland with brain and spinal cord metastases.