International ophthalmology · 2025
Investigation of conjunctival vasculature changes assessed by Anterior Segment Optical Coherence Tomography Angiography after photorefractive keratectomy: a pilot study.
СтатьяНазвание и аннотация: Перевод в очереди
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Mohammadi Abbas, Masihpour Nasrin, Hajizadeh Maryam, Salehzadeh Zohreh
Аннотация
PURPOSE: This prospective pilot study aimed to evaluate longitudinal changes in conjunctival microvascular morphology using Anterior Segment Optical Coherence Tomography Angiography (AS_OCTA) following photorefractive keratectomy (PRK) and to explore their relationships with visual outcomes and dry eye symptoms.
METHODS: In this prospective pilot study, fifteen patients undergoing PRK were assessed at baseline, 1 week, 1 month, and 3 months postoperatively. AS-OCTA was used to quantify superficial conjunctival vessel density (VD). Refractive and tomography values were evaluated concurrently. Exploratory correlations between vascular parameters, visual recovery, and tomography values were analyzed.
RESULTS: Visual acuity improved significantly after PRK, with mean UCVA advancing from 0.68 ± 0.08 preoperatively to 0.16 ± 0.08 at 1 month (p < 0.001), remaining stable through 3 months. Conjunctival vessel density (VD) decreased gradually from 0.38 ± 0.05 at baseline to 0.35 ± 0.05 at 3 months (p = 0.025). Exploratory correlation analyses within this pilot cohort showed a moderate positive correlation between 3-month VD and OSDI scores (r = 0.56, p = 0.03) and a moderate inverse correlation between 3-month VD and UCVA (r = -0.48, p = 0.07).
CONCLUSIONS: This pilot study demonstrates that PRK induces dynamic conjunctival microvascular changes, detectable by AS-OCTA. Our findings suggest that monitoring this microcirculation may provide insights into the postoperative healing process and potentially serve as a biomarker for recovery. The observed associations between vascularity, symptoms, and vision warrant further investigation in larger studies to confirm their clinical utility.
METHODS: In this prospective pilot study, fifteen patients undergoing PRK were assessed at baseline, 1 week, 1 month, and 3 months postoperatively. AS-OCTA was used to quantify superficial conjunctival vessel density (VD). Refractive and tomography values were evaluated concurrently. Exploratory correlations between vascular parameters, visual recovery, and tomography values were analyzed.
RESULTS: Visual acuity improved significantly after PRK, with mean UCVA advancing from 0.68 ± 0.08 preoperatively to 0.16 ± 0.08 at 1 month (p < 0.001), remaining stable through 3 months. Conjunctival vessel density (VD) decreased gradually from 0.38 ± 0.05 at baseline to 0.35 ± 0.05 at 3 months (p = 0.025). Exploratory correlation analyses within this pilot cohort showed a moderate positive correlation between 3-month VD and OSDI scores (r = 0.56, p = 0.03) and a moderate inverse correlation between 3-month VD and UCVA (r = -0.48, p = 0.07).
CONCLUSIONS: This pilot study demonstrates that PRK induces dynamic conjunctival microvascular changes, detectable by AS-OCTA. Our findings suggest that monitoring this microcirculation may provide insights into the postoperative healing process and potentially serve as a biomarker for recovery. The observed associations between vascularity, symptoms, and vision warrant further investigation in larger studies to confirm their clinical utility.